PYRIMIDINE METABOLISM REGULATOR-MEDIATED MOLECULAR SUBTYPES DISPLAY TUMOR MICROENVIRONMENTAL HALLMARKS AND ASSIST PRECISION TREATMENT IN BLADDER CANCER

BackgroundBladder cancer (BLCA) is a common urinary system malignancy with a significant morbidity and death rate worldwide.Non-muscle invasive BLCA accounts for over 75% of all BLCA cases.The imbalance of tumor metabolic pathways is associated with tumor formation and proliferation.Pyrimidine metabolism (PyM) is a complex enzyme network that incor

# *Full Quarter horse An indefinite quadratic programming problem is a mathematical programming problem which is a product of two linear factors.In this paper, the piecewise indefinite quadratic programming problem (PIQPP) is considered.Here, the objective function is a product of two continuous piecewise linear functions defined on a non-empty and

In this study a multi-technique analysis was performed on the decorated BB cream surfaces of four ancient pottery fragments dated back XIX century A.D.withdrawn from the archaeological site of the medieval Agsu town, in Azerbaijan.During the last decade, the site underwent to an extensively archaeometric investigation by means of different non-dest

Microperforated absorbers (MPA) are a well-established technology for attenuating sound Aromatherapy in flow carrying ducts.MPAs usually consist of a microperforated panel (MPP) in combination with a cavity as back volume.The damping maxima of MPAs occur in the range of their resonant frequencies and the effect is narrowband compared to porous or f